INTRODUCTION: Electronic prescription has become an important tool in Greece over the past decades. Regarding midwives, prescription writing is mandatory according to the provisions of Presidential Decree 351/1989. However, this law is not effectively implemented in clinical practice. OBJECTIVE: The study aimed to assess the level of knowledge among midwives regarding the prescription of medications, vaccines, and diagnostic tests. Specifically, the attitudes and knowledge of midwives regarding electronic prescription were investigated in Reception and Identification Centers and Refugee-Migrant Hosting Centers. Material and Methods: The questionnaire was completed by 95.6% of midwives working in Reception and Identification Centers and Refugee-Migrant Hosting Centers for the program "Integrated emergency health intervention for the refugee crisis" of the Hellenic National Public Health Organization (E.O.D.Y.). The questionnaire included questions about knowledge and attitudes regarding the prescription of medications, vaccines, and diagnostic tests. RESULTS: Of the participating midwives, 55.8% had professional experience of 1-5 years. 69.8% of midwives answered correctly to the knowledge questions regarding pharmaceutical preparations, while 58.1% stated that they are quite likely to seek information about the side effects of pharmaceutical preparations during the antenatal period on the internet as part of pharmacovigilance. 97.7% recommend the recommended examinations to migrant women, while 53.5% of midwives recommend the required vaccines for the antenatal period. The desire for access to electronic prescription services for medications (46.5%) and diagnostic tests (58.6%) is significantly associated (P < 0.001) with knowledge and attitudes towards prescription writing. Compliance of refugees-migrant women with the use of prescribed medications (p 0.010) and vaccines (p 0.004) is significantly associated with the midwives' prescription writing preference. However, it is not significantly associated with midwives' knowledge of medications (P 0.435), diagnostic and laboratory tests (P 0.692), and vaccines (P 0.332). CONCLUSIONS: The possibility of implementing electronic prescription by midwives in Reception and Identification Centers and Refugee-Migrant Hosting Centers is a significant strategic goal for the health of migrant women. Electronic prescription by midwives could help improve compliance with pharmaceutical treatment, vaccines, and laboratory and diagnostic tests among refugee-migrant women.